Clinical study of aromatic essential oil therapy in the treatment of type Ⅲ chronic prostatitis/chronic pelvic pain syndrome
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摘要: 目的 探讨芳香精油疗法治疗Ⅲ型慢性前列腺炎/慢性盆腔疼痛综合征(CP/CPPS)的安全性和有效性。方法 采用随机抽样法，选取2018年1月—2019年12月在复旦大学附属上海市第五人民医院泌尿外科就诊的Ⅲ型CP/CPPS的患者70例为研究对象，采用随机数字表法将其分为试验组和对照组，两组各35例。对照组在常规治疗的基础上采用甘油按摩腹股沟淋巴结和八髎穴，试验组采用自主研发的前列腺炎专用芳香精油进行按摩，每日2次，持续4周。比较干预前后两组患者美国国立卫生研究院慢性前列腺炎症状评分(NIH-CPSI)、国际前列腺症状评分(IPSS)、焦虑自评量表(SAS)评分和国际勃起功能指数(IIEF-5)及前列腺液实验室检查指标的变化情况。结果 共67例患者完成了全部治疗，均未发生不良反应。治疗4周后，试验组与对照组在疼痛、排尿、生活质量、NIH-CPSI总分、IPSS、SAS、IIEF-5评分、临床实验室检查评分等方面比较差异均无统计学意义(P＞0.05)，但试验组疼痛和不适范围较对照组明显减少(P＜0.01)，焦虑程度也显著下降(P＜0.01)。结论 芳香精油疗法治疗可减轻CP/CPPS患者的疼痛和不适，有效缓解焦虑。Abstract: Objective To assess the safety and effectiveness of aromatic essential oil therapy for type Ⅲ CP/CPPS.Methods In this study, 70 patients with type Ⅲ CP/CPPS who visited the department of urology, Shanghai Fifth People's Hospital, Fudan University were randomly allocated into the essential oil treatment group (n=35) and control group (n=35) from January 2018 to December 2019. The oil was smeared by self-massage on the inguinal lymph nodes and Ba Liao point twice a day and the total course of the treatment was 4 weeks. The National Institutes of Health Chronic Prostatitis Syndrome Index (NIH-CPSI), International Prostate Symptom Score (IPSS), Self-rating Anxiety Scale (SAS), International Index of Erectile Function Score (IIEF-5) and expressed prostatic secretions were measured before and after the intervention to evaluate the effects of essential oil.Results Sixty-seven patients were completed the total treatment. There were no notably differences between the study group and control group in terms of the pain, urination, quality of life, total score of NIH-CPSI, the score of the IPSS, SAS, IIEF-5 or the clinical laboratory examination (P > 0.05). In the treatment group, the domain of pain and discomfort was significantly reduced after 4 weeks of intervention in comparison with the control group (P < 0.01). The degree of anxiety was also significantly released (P < 0.01). No serious side effects occurred.Conclusion The treatment of aromatic essential oil can reduce the pain and discomfort in patients with CP/CPPS and efficiently release the anxiety.
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Key words:
- chronic prostatitis /
- chronic pelvic pain syndrome /
- aromatic essential oil therapy /
- pain /
- anxiety
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表 1 两组患者一般资料比较
例(%)，X±S 项目 试验组(n=34) 对照组(n=33) 年龄/岁 38.63±1.16 38.11±1.08 和配偶居住 20(58.82) 22(66.67) 每月性生活次数/次 2.26±0.26 2.37±0.37 CP史 16(47.06) 15(45.45) 主要症状 会阴部、盆底疼痛或不适 22(64.71) 24(72.73) 排尿疼痛 20(58.82) 23(69.70) 性功能异常 3(8.82) 2(6.06) 白细胞 异常 30(88.24) 27(81.82) 正常 4(11.76) 6(18.18) 卵磷脂 异常 25(73.53) 25(75.76) 正常 9(26.47) 8(24.24) 
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表 2 两组患者NIH-CPSI得分比较
分，X±S 组别 疼痛 排尿 生活质量 总分 试验组(n=34) 干预前 13.74±0.27 6.86±0.27 7.23±0.26 27.86±0.44 干预后 10.09±0.53 4.35±0.26 4.27±0.27 18.71±0.79 对照组(n=33) 干预前 13.03±0.44 6.77±0.28 7.17±0.26 26.97±0.58 干预后 12.18±0.58 4.88±0.37 4.09±0.24 21.15±0.96
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表 3 两组患者IPSS、SAS、IIEF-5得分比较
分，X±S 组别 IPSS SAS IIEF-5 试验组(n=34) 干预前 15.69±0.88 45.51±2.60 17.14±0.67 干预后 12.91±0.76 40.53±1.69 21.06±0.53 对照组(n=33) 干预前 16.09±0.68 47.86±2.08 17.73±0.67 干预后 13.71±0.84 47.52±1.75 18.00±0.43
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表 4 两组患者实验室指标比较
例(%) 组别 白细胞 卵磷脂 减少 正常 增多 减少 正常 增多 试验组(n=34) 6(17.65) 13(38.24) 15(44.12) 5(14.71) 16(47.06) 13(38.24) 对照组(n=33) 10(30.30) 11(33.33) 12(36.36) 6(18.18) 15(45.45) 12(36.36)
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