A therapeutic effect analysis of the comparative early intravesical instillation of pirarubicin versus traditional intravesical instillation of pirarubicin for superficial bladder cancer
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摘要: 目的：比较吡柔比星早期膀胱灌注与常规膀胱灌注对浅表性膀胱癌的术后疗效。方法：选用膀胱肿瘤患者79例，随机分为两组。早期组36例，术后6小时内开始膀胱灌注吡柔比星（THP）30 mg，以后1次/周，共8次，之后1次/月，连续10次，共18次。常规组43例，于术后5~7天开始第一次膀胱灌注化疗，其余方法与用量均与早期组相同。观察两组患者术后2年复发率和不良反应发生情况。结果：随访2年，早期组与常规组复发率分别为19.44%、34.88%，总不良反应率分别为63.89%、18.60%，差异有统计学意义（P<0.05）。结论：早期组预防浅表性膀胱癌复发效果优于常规组，虽然总不良反应率高于常规组，但患者均可耐受，无严重的不良反应。Abstract: Objective: To compare the therapeutic effect of the early intravesical instillation of pirarubicin and traditional intravesical instillation of pirarubicin for superficial bladder cancer.Methods: 79 patients suffered bladder cancer were randomly separated into the following groups:the early intravesical instillation group (n=36):in the early six hours after operation, we use 30 mg pirarubicin(THP) to instill the bladder once a week, sum to eight consecutive times. Then, the rate was changed to once a month, ten consecutive times. Traditional intravesical instillation group (n=43):from 5 to 7 days after operation, we conducted intravesical instillation first time, the methods and does were the same as the early intravesical instillation group. The research is to observe the the rate of recurrence and adverse effects after two years in two groups.Results: In two years follow up, the rate of recurrence between in the early intravesical instillation group and the traditional intravesical instillation group were 19.44% and 34.88%, and the rate of adverse effects were 63.89% and 18.60%. Statistical analysis showed that the differences have statistical significance(P<0.05).Conclusions: The results of the therapeutic effect suggested that the early intravesical instillation showed significant superiority compared with the traditional intravesical instillation in the prevention of tumor recurrence. Although the rate of adverse effects in the early intravesical instillation group was higher than the traditional intravesical instillation group, all patients could well tolerated and there was no one occured serious adverse reactions.
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Key words:
- bladder cancer /
- pirarubicin /
- early intravesical instillation /
- palindromia
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