前列腺胃肠外间质瘤1例报告并文献复习

刘志飞; 张志宏; 徐勇; 邓刚; 李印东

前列腺胃肠外间质瘤1例报告并文献复习

- 1. 河北省唐山市人民医院泌尿外科(河北唐山, 063000);
- 2. 天津医科大学第二医院泌尿外科, 天津市泌尿外科基础医学重点实验室

详细信息

通讯作者: 徐勇,E-mail:xuyong8816@sina.com

中图分类号: R697.3

收稿日期: 2012-08-14

Extragastrointestinal stromal tumor of the prostate: a case report and literature review

- 1. Department of Urology, Tangshan People's Hospital, Tangshan, Hebei, 063000, China;
- 2. Department of Urology, Second Hospital of Tianjin Medical University, Institute of Urology

More Information

Corresponding author: XU Yong, E-mail: xuyong8816@sina.com

Received Date: 14 August 2012

摘要

摘要: 目的：提高前列腺胃肠外间质瘤的诊治水平。方法：回顾性分析1例前列腺胃肠外间质瘤的临床和影像资料，并结合相关文献讨论。该患者入院诊断前列腺肉瘤，为明确诊断行经直肠超声引导前列腺穿刺术。结果：活检穿刺组织病理报告：光镜下肿瘤细胞密集，排列紊乱，以梭形细胞为主；免疫组化标记：CD117和CD34表达阳性，PSA、S-100和SMA阴性，支持前列腺胃肠外间质瘤诊断。行伊马替尼靶向治疗，随访6个月肿瘤无明显缩小，至今仍存活。结论：前列腺胃肠外间质瘤极为罕见，确诊主要依靠病理诊断和免疫组织化学，除外胃肠道来源，影像学检查可提供直接依据。外科手术治疗效果较好。靶向药物治疗前列腺胃肠外间质瘤的作用还有争论。
- 前列腺 /
- 胃肠道外间质瘤 /
- 靶向治疗
Abstract: Objective: To evaluate the diagnosis and the treatment of the extragastrointestinal stromal tumor of the prostate and to raise awareness of the disease. Methods: The clinical and imaging data of a case of EGIST patient were analyzed retrospectively and discussed with relative literature review. A presumptive diagnosis of primary prostate sarcoma was made and TRUS-guided biopsies were taken. Results: Histologically, the tumor consisted of spindle-shape cells, with irregular dense arrangement. Immunohistochemically, the tumor cells were positive for CD117 and CD34, but negative for PSA, SMA and S-100. The pathologic diagnosis of prostatic EGIST was made based on characteristic morphological features, immunoprofiles, and imagings analysis. Imatinib was used to treat with this tumor. During the follow-up period of 6 months the lesion did not shrinked obviously and the patient was still alive. Conclusion: Prostatic EGIST is rare. The diagnosis of prostatic EGIST is based on characteristic morphological features and immunohistochemistry by prostate needle biopsy. Rectal GIST was excluded by radiology and transrectal ultrasonography. Complete resection of the tumor is effective in treating EGIST. Data suggest that the therapeutic efficacy of drug targeted treatment in prostatic EGIST is disputed.
- prostate /
- extragastrointestinal stromal tumor /
- targeted therapy

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参考文献(15)

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