Galectin-3和CD44v6的表达与前列腺癌转移及预后的关系

赵朋; 刘德祥; 于斌; 张庆皎; 田丁; 刘博; 马春磊; 胡海龙; 白铁男; 孙光

Galectin-3和CD44v6的表达与前列腺癌转移及预后的关系

- 1. 天津市第四中心医院泌尿外科(天津, 300140);
- 2. 天津医科大学第二医院泌尿外科
基金项目:
天津市应用基础及前沿技术研究计划基金资助项目（编号09JCYBJC27800）；天津市卫生局科技基金资助项目（编号09KZ90）

详细信息

通讯作者: 赵朋,E-mail:zhaopeng198607.27@163.com

中图分类号: R737.25

收稿日期: 2012-11-19

Expression of Galectin-3 and CD44v6 protein in prostatic carcinoma and its metastasis and prognosis

- 1. Department of Urology, Tianjin Forth Central Hospital, Tianjin, 300140, China;
- 2. Department of Urology, the Second Hospital of Tianjin Medical University

More Information

Corresponding author: ZHAO Peng, E-mail: zhaopeng198607.27@163.com

Received Date: 19 November 2012

摘要

摘要: 目的：探讨Galectin-3和CD44v6蛋白表达与前列腺癌（PCa）临床病理特征和预后的关系。方法：应用免疫组织化学技术检测45例PCa、25例PIN和20例BPH组织中Galectin-3和CD44v6蛋白表达，并结合肿瘤的病理学行为和临床随访资料进行分析。结果：在PCa组织中，Galectin-3和CD44v6阳性表达率分别为（82.2±59.5）%、（75.6±24.0）%，均显著高于PIN和BPH组织（P<0.05）。Galectin-3和CD44v6表达与肿瘤分化程度、周围淋巴结转移、远处转移、预后密切相关（P<0.05）。Galectin-3和CD44v6蛋白表达呈显著正相关（r=0.412，P=0.005）。结论：Galectin-3和CD44v6蛋白表达与PCa发生、转移和患者生存期密切相关，联合检测可以对PCa的发生、发展、预后及药物治疗提供重要依据。
- 前列腺癌 /
- Galectin-3蛋白 /
- CD44V6蛋白
Abstract: Objective: To investgate the expression of Galectin-3 and CD44v6 protein in prostatic carcinoma and their relationship with metastatsis and prognosis.Methods: Immunohistochemical staining was used to detect the expression of Galectin-3 and CD44v6 protein in 45 cases of prostatic carcinoma, 25 cases of PIN and 20 cases of BPH. The study was also combined with analysis of the pathological behavior and clinical follow-up survey of prostatic carcinoma.Results: The positive expression rate of Galectin-3 and CD44v6 was (82.2%±59.5%), (75.6%±24.0%), which was higher than that in PIN and BPH(P<0.05). The expression of Galectin-3 and CD44v6 was closely related to the degree of histological grade, metastasis of lymph node, distant metastasis and prognosis of patients (P<0.05). Positive correlation was found between Galectin-3 and CD44v6 proteion(r=0.412, P=0.005).Conclusion: These data suggest that the expression of Galectin-3 and CD44v6 is closely related to carcinogenesis, metastasis and survival rate in prostatic carcinoma patients. The combined detection of Galectin-3 and CD44v6 proteins can be used to evaluate the incidence of prostate carcinoma development, prognosis, and provide an important basis for drug treatment.
- prostatic carcinoma /
- Galectin-3 /
- CD44v6

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参考文献(10)

[1]	Szöke T, Kayser K, Trojan I, et al. The role of microvascu-larization and growth/adhesion-regulatory lectins in the prognosis of non-small cell lung cancer in stageⅡ[J]. Eur J Cardiothorac Surg, 2007, 31:783-787.
[2]	Nagy N, Legendre H, Engels O, et al. Refined prognostic evaluation in colon carcinoma using immunohistochemical Galectin fingerprinting[J]. Cancer, 2003, 97:1849-1858.
[3]	Hittelet A, Legendre H, Nagy N, et al. Upregulation of Galectins-1 and-3 in human colon cancer and their role in regulating cell migration[J]. Int J Cancer, 2003, 103:370-379.
[4]	Ulmer T A, Keeler V, Loh L, et al. Tumor-associated antigen 90K/Mac-2-binding protein:possible role in colon cancer[J]. J Cell Biochem, 2006, 98:1351-1366.
[5]	Endo K, Kohnoe S, Tsujita E, et al. Galectins-3 expression is a potent prognostic marker in colorectal cancer[J]. Anticancer Res, 2005, 25:3117-3121.
[6]	Yoshida R, Kimura N, Harada Y, et al. The loss of E-cadherin, alpha-and beta-catenin expression is associated with metastasis andpoor prognosis in invasive breast cancer[J]. Int J Oncol, 2001, 18:513-520.
[7]	Marhaba R, Bourouba M, Zöller M. CD44V6 promotes proliferation by persisting activation of MAP kinases[J]. Cell Signal, 2005, 17:961-973.
[8]	Chen J Q, Zhan W H, He Y L, et al. Expression of heparanase gene, CD44v6, MMP7 and nm23 protein and their relationship with invasion and metastasis of gastric carcinomas[J]. World J Gastroenterol, 2004, 10:776-782.
[9]	Rathmell J C. B-cell homeostasis:digital survival or analog growth[J]? Immunol Rev, 2004, 197:116-128.
[10]	Zheng J Y, Wang W Z, Li K Z, et al. Effect of p27(KIP1) on cell cycle and apoptosis in gastric cancer cells[J]. Word J Gastroenterol, 2005,11:7072-7077.