跨膜蛋白MS4A8B在前列腺癌组织中的表达及意义

叶林; 万方宁; 沈旭霞; 孙娟娟; 瞿元元; 卞晓洁; 李健; 刘晓军; 戴波; 张世林; 姚旭东; 叶定伟

跨膜蛋白MS4A8B在前列腺癌组织中的表达及意义

- 1. 复旦大学附属肿瘤医院泌尿外科, 复旦大学上海医学院肿瘤学系(上海, 200032);
- 2. 复旦大学附属肿瘤医院病理科, 复旦大学上海医学院肿瘤学系
基金项目:
中国博士后科学基金资助项目（编号2013M531123）；上海市博士后科研资助计划面上项目（编号12R21411600）；国家自然科学基金资助项目（编号30973009）

详细信息

通讯作者: 叶定伟,E-mail:dwye@shca.org.cn

中图分类号: R737.25

收稿日期: 2013-06-20

The expression and clinical significance of MS4A8B in prostate cancer tissue

- 1. Department of Urology, Fudan University Shanghai Cancer Center;Department of Oncology, Shanghai Medical College of Fudan University, Shanghai, 200032, China;
- 2. Department of Pathology, Fudan University Shanghai Cancer Center;Department of Oncology, Shanghai Medical College of Fudan University

More Information

Corresponding author: YE Dingwei, E-mail: dwye@shca.org.cn

Received Date: 20 June 2013

摘要

摘要: 目的：探讨跨膜蛋白MS4A8B在前列腺癌组织中的表达及意义。方法：采用免疫组织化学检测140例临床局限性前列腺癌行前列腺癌根治术样本的组织微阵列芯片上的MS4A8B，并将MS4A8B与增殖指数（PCNA）和凋亡指数（TUNEL）进行相关性分析，将患者的年龄、PSA水平、Gleason评分及生化复发等临床病理特征与MS4A8B进行统计学处理。结果：良性组织、癌旁组织、前列腺上皮内瘤变、前列腺原发癌和前列腺转移淋巴结的MS4A8B蛋白表达分别为0%、1.94%、5.92%、62.6%和70.4%。Kaplan-Meier生存曲线分析表明前列腺癌组织高表达患者较低表达患者无生化复发生存时间（RFS）明显缩短（P<0.05）；进一步研究发现MS4A8B蛋白表达与患者Gleason评分、增殖指数呈正相关（Spearman分析）（P<0.001）。结论：MS4A8B的表达与前列腺癌根治术后生化复发和转移相关，并在前列腺癌进展中扮演重要角色。
- 前列腺癌 /
- MS4A8B蛋白 /
- 生化复发
Abstract: Objective: To clarify the expression and clinical significance of MS4A8B in prostate cancer.Methods: In 140 clinically localized prostate cancer tissue samples undergoing radical prostatectomy, immunohistochemical staining was performed. Statistical analysis was used to determine the correlation between MS4A8B and PCNA protein level as an index of proliferative activity, TUNEL staining as an index of apoptosis. We further analyzed statistically the value of the MS4A8B expression evaluating clinicopathological characteristics such as age, PSA at diagnosis, Gleason score, and biochemical recurrence. Results: Positive ratios of MS4A8B protein expression were 0%, 1.94%, 5.92%, 62.6% and 70.4% in benign, benign adjacent to prostate cancer, HPIN, primary and metastatic prostate cancer, respectively. Kaplan-Meier curves revealed that the recurrence-free survival (RFS) of the patients with high MS4A8B expression were shorter than that with low MS4A8B expression. Moreover, MS4A8B was positively associated with Gleason score, the proliferation index (all p<0.001).Conclusions: MS4A8B expression is associated with early biochemical relapse and metastasis after radical prostatectomy which plays an important role in progression of human prostate cancer
- prostate cancer /
- MS4A8B /
- biochemical recurrence

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