5-羟色胺2受体对排尿影响的研究进展

陈加生, 谷宝军. 5-羟色胺2受体对排尿影响的研究进展[J]. 临床泌尿外科杂志, 2012, 27(9): 717-720.
引用本文: 陈加生, 谷宝军. 5-羟色胺2受体对排尿影响的研究进展[J]. 临床泌尿外科杂志, 2012, 27(9): 717-720.

5-羟色胺2受体对排尿影响的研究进展

  • 基金项目:

    国家自然科学基金项目(编号30872568);上海市科委启明星追踪项目(编号09QH1402000)

详细信息
    通讯作者: 谷宝军,E-mail:baojun70@sohu.com
  • 中图分类号: Q517;R334

  • 下尿路储尿和排尿功能主要由脊髓反射和脊上神经中枢介导。许多研究表明5-羟色胺(5-HT)受体对调节这两个通路均有显著作用,其中尤以5-HT1A受体为甚,其次为5-HT2、5-HT3和5-HT7受体。5-HT2受体分为5-HT2A、5-HT2B、5-HT2C三种亚型,其中对排尿有影响的主要为5-HT2A、5-HT2C这两种亚型。本文主要就5-HT2受体的结构、分布、药理作用以及5-HT2受体对排尿影响的研究进展作一综述。
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  • [1]

    KELLY A B, CLARKE W P, CUNNINGHAM K A, et al. Fine-tuning serotonin2c receptor function in the brain:molecular and functional implications[J]. Neuropharmacoloy, 2008, 55:969-976.

    [2]

    BERG K A, HARVEY J A, SPAMPRINATO U, et al. Physiological and therapeutic relevance of constitutive activity of 5-HT2A and 5-HT2C receptors for the treatment of depression[J]. Prog Brain Res, 2008, 172:287-305.

    [3]

    KROEZE W K, KRISTIANSEN K, ROTH B L. Molecular biology of serotonin receptors structure and function at the molecular level[J]. Curr Top Med Chem, 2002, 2:507-528.

    [4]

    LEYSEN J E. 5-HT2 Receptors[J]. Curr Drug Targets CNS Neurol Disord, 2004, 3:11-26.

    [5]

    XU C, GIULIANO F, SUN X Q, et al. Serotonin 5-HT2A and 5-HT5A receptors are expressed by different motoneuron populations in rat Onuf's nucleus[J].J Comp Neurol,2007,502:620-634.

    [6]

    BREA J, CASTRO-PALOMINO J, YESTE S, et al. Emerging opportunities and concerns for drug discovery at serotonin 5-HT2B receptors[J]. Curr Top Med Chem, 2010, 10:493-503.

    [7]

    KENNETT G A, WOOD M D, BRIGHT F, et al. SE 242084, a selective and brain penetrant 5-HT2C receptor antagonist[J]. Neuropharmacology,1997, 36:609-620.

    [8]

    DOWD C S, HERRICK-DAVIS K, EGAN C, et al. 1-[4-(3-Phenylalkyl)phenyl]-2-aminopropanes as 5-HT2A) partial agonists[J]. J Med Chem, 2000, 43:3074-3084.

    [9]

    VAN OEKELEN D, MEGENS A, MEERT T. Functional study of rat 5-HT2A receptors using antisense oligonucleotides[J]. J Neurochem, 2003, 85:1087-1100.

    [10]

    JENSEN N H, CREMERS T I, SOTTY F, et al. Therapeutic potential of 5-HT2C receptor ligands[J].Scientific World Journal, 2010,10:1870-1885.

    [11]

    ANDREW M D, FISH P V, BLAGG J, et al. Pyrimido[4,5-d] azepines as potent and selective 5-HT2C receptor agonists:Design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence[J]. Bioorg. Med Chem Lett, 2010, 21:2175-2720.

    [12]

    LEE J, JUNG L M, LEE J H. 5-HT2C receptor modulators:a patent survey[J]. Expert Opin Ther Pat, 2010, 20:1429-1455.

    [13]

    DOLY S, MADEIRA A, FISCHER J, et al. The 5-HT2A receptor is widely distributed in the rat spinal cord and mainly localized at the plasma membrance of postsynaptic neurons[J]. J Comp Neurol, 2004, 472(2):496-511.

    [14]

    ZENG F Q, XU C, XU G. Distribution of serotonin 5-HT2A and 5-HT7 receptors in the Onuf's nucleus of the rat spinal cord[J]. Neural Regen Res, 2008, 3(8):853-857.

    [15]

    STEERS W D, DE GROAT W C. Effects of mchlorophenylpiperazine on penile and bladder function in rats[J]. Am J Physiol, 1989, 257:R1441-R1449.

    [16]

    GUARNERI L, IBBA M, TESTA R, et al. The effects of mCPP on bladder voiding contractions in rats are mediated by the 5-HT2A/5-HT2C receptors[J]. Neurourol Urodyn,1996,15:316-317(abstracts).

    [17]

    DE GROAT W C. Influence of central serotonergic mechanisms on lower urinary tract function[J]. Urology, 2002, 9(5 Suppl 1):30-36.

    [18]

    TESTA R, GUARNERI L, ANGELIC P. Effect of different 5-hydroxytryptamine receptor subtype antagonists on the micturition reflex in rats[J]. Br J Urol Int,2001,87:256-264.

    [19]

    DANUSER H, THOR K B. Spinal 5-HT2 receptor-mediated facilitation of pudendal nerve reflexes in the anaesthetized cat[J]. Br J Pharmacol,1996,118:150-154.

    [20]

    MCNURRAY G, MINER W D. The effect of the 5-HT2C agonist Ro600175 on urinary cystometric parameters in the guinea pig[J]. FASEB,2005,19:Abstract #320.3.

    [21]

    CONLON K, MINER W, MCCLEARY S, et al. Identification of 5-HT2C mediated mechanisms involved in urethral sphincter reflexes in a guinea-pig model of urethral function[J]. BJU International, 2011:1464-146x.

    [22]

    MBAKI Y, WESTBROOK S L, RAMAGE A G.The role of 5-HT2 receptors subtypes in the control of the urethra and micturition in anaesthetized female rats[J]. Proceeding of BPS meeting December 2005 UCL London.

    [23]

    MBAKI Y, RAMAGE A G. Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat[J]. 2008,155:343-356.

    [24]

    MBAKI Y, RAMAGE A G, MCNURRAY G, et al. 5-HT2A receptor activation of the external urethral sphincter and 5-HT2C receptor inhibition of micturition:A study based on pharmacokinetics in the anaesthetized female rat[J]. Eur J Pharmacol, 2012, 682:142-152.

    [25]

    KADEKAWA K, NISHIJIMA S, SUGAYA K, et al. Mechanisms by which the serotonergic system inhibits micturition in rats[J]. Life Sci, 2009, 85:592-596.

    [26]

    ISHIZUKA O, GU B J, IGAWA Y, et al. Role of supraspinal serotonin receptors formicturition in normal conscious rats[J]. Neurourol Urodyn,2002,21:225-230.

    [27]

    CORSI M, TOSON P G, PIETRA G, et al. Pharmacological analysis of 5-hydroxytryptamine effects on electrically stimulated human isolated urinary bladder[J]. Br J Pharmacol,1991,104:719-725.

    [28]

    MESSORI E, RIZZI C A, CANDURA S M, et al. 5-Hydroxytryptamine receptors that facilitate excitatory neuromuscular transmission in the guinea-pig isolated detrusor muscle[J]. Br J Pharmacol, 1995, 115:677-683.

    [29]

    REKIK M, LLUEL P, PALEA S. 5-Hydroxytr-yptamine potentiates neurogenic contractions of rat isolated urinary bladder through both 5-HT7 and 5-HT2C receptors[J]. Eur J Pharmacol,2011,650:403-410.

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出版历程
收稿日期:  2012-05-17

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