前列腺增生症患者尿路感染细菌的耐药性分析

李涛; 张鹏; 朱绪辉; 善辉; 杜鹏

前列腺增生症患者尿路感染细菌的耐药性分析

- 首都医科大学附属北京朝阳医院(京西院区)泌尿外科(北京, 100043)

详细信息

通讯作者: 杜鹏,E-mail:E-mail:dupeng9000@126.com

中图分类号: R691.3

收稿日期: 2012-02-20

The analyze of micro-organism antimicrobial resistance in the BPH patients of UTI

- Department of Urology, Jing-xi Campus of Beijing Chaoyang Hospital, Capital University of Medical Sciences, Beijing, 100043, China

More Information

Corresponding author: DU Peng, E-mail: dupeng9000@126.com

Received Date: 20 February 2012

摘要

摘要: 目的：分析BPH患者下尿路感染的细菌谱和耐药性，为医生应用敏感抗生素提供参考。方法：回顾性分析了2005年6月~2011年1月我院370例BPH患者尿培养结果。结果：尿培养阳性者共144例（38.9%），平均年龄50~87（70.94±8.80）岁。前五位细菌：大肠埃希氏杆菌（25.0%）、粪肠球菌（15.3%）、溶血葡萄球菌（9.7%）、铜绿假单胞菌（9.0%）和肺炎克雷伯菌（6.9%）。大肠埃希氏菌，对所有抗生素的耐药性都大于20%。75%以上细菌为复合耐药菌。其中青霉素的耐药性是最高，依次是头孢类抗生素、喹诺酮类和磺胺类药物。结论：BPH患者下尿路感染的细菌中，大肠杆菌是最主要的细菌，75%以上细菌为复合耐药菌。对于复合耐药菌治疗中，青霉素和头孢类抗生素应该慎用。应长期动态观察BPH患者下尿路细菌谱和耐药性的变化。
- 尿路感染 /
- 前列腺增生 /
- 耐药性
Abstract: Objective: To analyze micro-organisms demography and resistance characteristics in the BPH patients of lower UTI and provide for doctors with sensitive antibiotics.Method: From June 2005 to January 2011,all of 370 urine samples of BPH were sent to be cultivated.Result: One hundred and forty-four(38.9%)were positive. The mean age of patients was (70.94±8.80) years old. The five valuable microorganisms:Escherichia coli(25.0%),E.faecalis(15.3%),Staphylococcus(9.7%)Pseudomonas aeruginosa(9.0%)and Klebsiella pneumoniae(6.9%). The resistance of Escherichia coli to all antimicrobial was >20%. Over 75% of all positive micro-organism were multiple-resistant. Of all medicine-resistant bacteria,penicillin was the highest resistance,the next three were Cephalosporins,Quinolones and trimethoprim-sulfamethoxazole respectively.Conclusion: Escherichia coli is a major microorganism in BPH of patients with UTI. Positive bacteria >75% are all multiple-resistance. We should pay more attention to the use of penicillin and Cephalosporins in the therapy of multiple-resistance microorganisms. Therefore,it is necessary that long-term and dynamic observations should be done to change of the micro-organisms demography in BPH patients.
- UTI /
- BPH /
- antimicrobial resistance

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参考文献(10)

[1]	HIRST G H,WARD J E. Clinical practice guidelines:reality bites[J]. Med J Aust,2000,172:287-291.
[2]	HUANG X,SHI H B,WANG X H,et al. Bacteriuria after bipolar transurethral resection of the prostate:risk factors and correlation with leukocyturia[J]. Urology,2011,77:1183-1187.
[3]	RASSWEILER J,TEBER D,KUNTZ R,et al. Complications of transurethral resection of the prostate(TURP)——incidence,management,and prevention[J]. Eur Urol,2006,50:969-979;discussion 980.
[4]	CASTRO-OROZCO R, BARRETO-MAYA A C, GUZMÁN-ÁLVAREZ H, et al. Antimicrobial resistance pattern for gram-negative uropathogens isolated from hospitalised patients and outpatients in Cartagena,2005-2008[J]. Rev Salud Publica(Bogota),2010,12:1010-1019.
[5]	BERGOGNE-BÉRÉZIN E. Lower urinary tract infections:bacterial epidemiology and recommendations[J]. Prog Urol,2008,18(1 Suppl FMC):F11-14.
[6]	BEAN D C,KRAHE D,WAREHAM D W. Antimicrobial resistance in community and nosocomial Escherichia coli urinary tract isolates,London 2005-2006[J]. Ann Clin Microbiol Antimicrob,2008,7:13.
[7]	MCLSAAC W J,MAZZULLI T,PERMAUL J,et al. Community-acquired antibiotic resistance in urinary isolates from adult women in Canada[J]. Can J Infect Dis Med Microbiol,2006,17:337-340.
[8]	SMITH S P,MANGES A R,RILEY L W. Temporal changes in the prevalence of community-acquired antimicrobial-resistant urinary tract infection affected by Escherichia coli clonal group composition[J]. Clin Infect Dis,2008,46:689-695.
[9]	MANGES A R,PERDREAU-REMINGTON F,SOLBERG O,et al. Multidrug-resistant Escherichia coli clonal groups causing community-acquired bloodstream infections[J]. J Infect,2006,53:25-29.
[10]	COSTELLOE C, METCALFE C, LOVERING A, et al. Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients:systematic review and meta-analysis[J]. BMJ,2010,340:c2096.