武汉地区非淋菌性尿道炎患者泌尿生殖道支原体感染及药敏分析

陈琪; 潘铁军; 沈国球; 周杰

武汉地区非淋菌性尿道炎患者泌尿生殖道支原体感染及药敏分析

- 广州军区武汉总医院泌尿外科(武汉, 430070)

详细信息

通讯作者: 陈琪,E-mail:chenqi210@sohu.com

中图分类号: R695

收稿日期: 2013-04-17

Analysis of urogenital tract mycoplasma infection and drug sensitivity for NGU patients in Wuhan region

- Department of Urology, Wuhan General Hospital, Guangzhou Command of PLA, Wuhan, 430070, China

More Information

Corresponding author: CHEN Qi, E-mail: chenqi210@sohu.com

Received Date: 17 April 2013

摘要

摘要: 目的：调查武汉地区非淋菌性尿道炎（NGU）患者泌尿生殖道支原体感染及耐药情况，为临床选择治疗支原体感染的抗生素提供参考依据。方法：采用支原体分离、鉴定、计数、药敏试剂盒检测拟诊为NGU患者的解脲脲原体（UU）和人型支原体（MH），并分析药敏试验结果。结果：630例患者中支原体总阳性率38.6%，以UU（30%）感染为主，男性感染率明显高于女性。药敏试验结果显示，UU、MH和UU+MH对药物的敏感性最高者依次为阿奇霉素和美满霉素，UU对氧氟沙星、司帕沙星和罗红霉素耐药性高，MH及UU+MH则对罗红霉素、红霉素和克拉霉素耐药性高。结论：UU成为本地区NGU的主要病原体，治疗本地区泌尿生殖道支原体感染可首选阿奇霉素和美满霉素。
- 尿道炎 /
- 支原体 /
- 抗生素 /
- 药敏试验
Abstract: Objective: To investigate urogenital mycoplasma infection and drug resistance in patients with non-gonococcal urethritis (NGU) in Wuhan city in order to provide a reference for choosing antibiotics in treating mycoplasma infection. Method: Mycoplasma separation, identification, counting, susceptibility kit were used to detect Ureaplasma urealyticum (UU) and Mycoplasma hominis (MH) in suspected patients with NGU, and analyzed the results of susceptibility test. Result: The total mycoplasma positive rate was 38.6% in 630 patients, and mainly was UU infection (30%). The infection rate in men was significantly higher than women. The results of susceptibility test showed that azithromycin and minocycline were the most sensitive to UU, MH respectively and UU + MH together. Ofloxacin, sparfloxacin and roxithromycin emerged drug resistance in UU. Roxithromycin, erythromycin and clarithromycin were not sensitive to MH or UU + MH. Conclusion: UU is the main pathogen of NGU in this region. Azithromycin and minocycline could be the priority for the treatment of urogenital mycoplasma infection.
- urethritis /
- mycoplasma /
- antibiotic /
- susceptibility test

HTML全文

参考文献(12)

[1]	吴移谋, 叶元康主编. 支原体学[M]. 北京:人民卫生出版社, 2009:391-395.
[2]	Deguchi T, Ito S, Hagiwara N, et al. Antimicrobial chemotherapy of Mycoplasma genitalium-positive non-gonococcal urethritis[J]. Expert Rev Anti Infect Ther, 2012, 10(7):791-803.
[3]	李俊. 非淋病性尿道炎患者解脲脲支原体耐药性分析[J]. 中华医院感染学杂志, 2012, 22(1):208-209.
[4]	Ito S, Yasuda M, Seike K, et al. Clinical and microbiological outcomes in treatment of men with non-gonococcal urethritis with a 100-mg twice-daily dose regimen of sitafloxacin[J]. J Infect Chemother, 2012, 18(3):414-418.
[5]	Paralanov V, Lu J, Duffy L B, et al. Comparative genome analysis of 19 Ureaplasma urealyticum and Ureaplasma parvum strains[J]. BMC Microbiol, 2012, 12:88.
[6]	EI Hajjaji I, Mansencal N, Dubourg O. Diagnosis of Cardiobacterium hominis endocarditis:usefulness of positron emission tomography[J]. Int J Cardio, 2012, 160(1):e3-e4.
[7]	张萍, 黄宏兰, 黄金娥, 等. 解脲支原体和人型支原体培养及药敏分析[J]. 中国感染控制杂志, 2009, 8(6):428-429.
[8]	钟少琴. 1760例NGU患者支原体培养鉴定及药敏分析[J]. 广东医学, 2009, 40(6):34-35.
[9]	黄日皎,王东山,许显芳. 690例泌尿生殖道感染患者支原体培养及药敏分析[J]. 检验医学与临床, 2009, 6(20):1709-1710.
[10]	倪培华, 应雅韵, 吴向前, 等. 解脲脲原体与女性生殖泌尿道感染的研究[J].上海医学检验杂志, 1997, 12(1):41-43.
[11]	张卫华. 泌尿生殖道支原体感染及对不同抗生素体外敏感情况分析[J]. 吉林医学, 2012, 33(32):7056-7057.
[12]	Akhtar M, Hirt H, Zurek L. Horizontal transfer of the tetracycline resistance gene tetM mediated by pCF10 among Enterococcus faecalis in the house fly (Musca domestica L.) alimentary canal[J]. Microbial Ecol, 2009, 58(3):509-518.