膀胱移行细胞癌组织中前胸腺素α的表达及其临床意义

林哲; 邓玮明; 何娅娣; 李辽源

膀胱移行细胞癌组织中前胸腺素α的表达及其临床意义

- 1. 中山大学附属佛山医院佛山市第一人民医院泌尿外科(广东佛山, 528000);
- 2. 中山大学附属第三医院泌尿外科;
- 3. 中山大学附属第三医院体检中心
基金项目:
2008年广东省医学科研基金项目（编号B2008164）；第42批中国博士后科学基金项目（编号20070420795）；第一批中国博士后科学基金特别资助项目（编号200801264）

详细信息

通讯作者: 李辽源,E-mail:liliao10318023@126.com

中图分类号: R737.14

收稿日期: 2012-03-19

The clinical significance of Prothymosin-α protein expression in human bladder transitional cancer

- 1. Department of Urology, the First People's Hospital of Foshan City, Foshan, 528000, China;
- 2. Department of Urology;
- 3. Department of Health Care Center, The Third Affiliated Hospital, Sun Yat-sen University

More Information

Corresponding author: LI Liaoyuan, E-mail: liliao10318023@126.com

Received Date: 19 March 2012

摘要

摘要: 研究前胸腺素α（PTMA）在膀胱移行细胞癌组织中的表达情况，并分析其与膀胱癌临床病理特征的关系。方法：选择96例膀胱移行细胞癌标本，10例癌旁正常膀胱组织标本。采用免疫组化检测膀胱癌和癌旁正常组织中PTMA蛋白的表达。癌标本中非肌层浸润性癌51例，肌层浸润性癌45例；单发肿瘤57例，多发肿瘤39例；G₁ 22例、G₂ 31例、G₃ 43例；非肌层浸润性癌中未复发29例，复发22例。结果：随病理分级和临床分期增加，PTMA相对表达量逐渐增高。G₁、G₂、G₃膀胱癌PTMA蛋白表达阳性率分别为13.6%、32.3%，62.8%，均差异有统计学意义（P<0.05）。正常膀胱组织中无PTMA蛋白表达。非肌层浸润性肿瘤和肌层浸润性肿瘤中PTMA蛋白表达阳性率为37.3%和77.8%，差异有统计学意义（P=0.0002）。随访12~60个月，非肌层浸润性膀胱癌中，复发组与未复发组中PTMA蛋白高表达阳性率为68.2%和31.0%，差异有统计学意义（P<0.001））。结论：检测膀胱移行细胞癌组织中PTMA有助于膀胱癌的诊断及评估判断，PTMA蛋白高表达与膀胱尿路上皮癌的恶性程度及预后相关。
- 膀胱移行细胞癌 /
- 前胸腺素α /
- 复发
Abstract: Objective: To explore the expression of Prothymosin-α (PTMA) in bladder transitional cell carcinoma and analyze its clinical significance and relationship with tumor recurrence. Methods: The expressions of PTMA protein in 96 specimens of bladder cancer and 10 specimens of normal bladder tissues were detected by immunohistochemical staining and its clinical significance was analyzed.Results: PTMA protein expression rates were 13.6%,32.3%,and 62.8% in G₁,G₂,and G₃ tumors,respectively(P<0.05).PTMA protein expression was higher in muscle invasive bladder cancers than in non-muscle invasive bladder cancer (77.8% versus 37.3%,P=0.0002).The expression of PTMA protein was higher in bladder cancer than that in the adjacent normal tissues.In patients with non-muscle invasive bladder cancer,PTMA protein expression was significantly higher in patients with recurrence than in those without recurrence (68.2% versus 31.0%,P<0.001).Conclusions: The determination of PTMA protein expression is potentially valuable in diagnosis and prognostic evaluation for bladder transitional cell carcinoma.
- bladder transitional cell carcinoma /
- Prothymosin-α /
- recurrence

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