转录因子FOXO1在前列腺癌组织中的表达及临床意义

瞿根义; 徐勇; 聂海波; 阳光

doi:10.13201/j.issn.1001-1420.2019.04.011

转录因子FOXO1在前列腺癌组织中的表达及临床意义

- 中南大学湘雅医学院附属株洲医院泌尿外科(湖南株洲, 412007)
基金项目:
株洲市科技指导性计划项目(编号20180004)

详细信息

通讯作者: 徐勇,E-mail:tigerhnll@126.com

中图分类号: R737.25

收稿日期: 2018-03-13

Expression and clinical significance of transcription factor FOXO1 in prostate cancer tissues

- Department of Urology, Affiliated Zhuzhou Hospital of Xiangya Medical College, Zhuzhou, Hunan, 412007, China

More Information

Corresponding author: XU Yong, E-mail: tigerhnll@126.com

Received Date: 13 March 2018

摘要

摘要: 目的:检测前列腺癌(PCa)组织与良性前列腺增生(BPH)组织中转录因子FOXO1的表达情况,探讨FOXO1与PCa临床病理参数之间的关系。方法:收集2010年1月~2016年12月我院53例PCa患者行根治性前列腺切除术后病理标本和经尿道前列腺电切术的53例BPH病理标本,采用组织芯片方式收集组织标本,使用免疫组化染色法检测FOXO1表达情况,分析FOXO1表达同PCa患者临床病理参数之间的关系。结果:BPH组织中FOXO1呈高表达,PCa组织中FOXO1表达显著低于BPH组织(39.6%vs.86.8%,P＜0.05),中低危PCa组织的相对表达量显著高于高危PCa组织(P＜0.05)。FOXO1表达与PCa PSA水平、病理T分期、淋巴结转移、Gleason评分显著相关(P＜0.05),Gleason评分越高FOXO1水平越低,PCa组织中FOXO1表达与患者年龄、前列腺体积、切缘阳性无明显相关性(P＞0.05)。结论:FOXO1在PCa组织中异常低表达,与PCa侵袭转移相关,FOXO1表达与PCa PSA水平、病理T分期、淋巴结转移和Gleason评分密切相关。
- FOXO1 /
- 前列腺癌 /
- 免疫组化 /
- 病理参数
Abstract: Objective: To detect the expression of FOXO1 in prostate cancer(PCa) and benign prostatic hyperplasia(BPH) tissues, and to investigate the relationship between FOXO1 and clinicopathological parameters in PCa. Method: Fifty-three cases of PCa pathology specimens and 53 cases of BPH pathology specimens after TURP from January 2010 to December 2016 in our hospital were collected. Tissue samples were collected by tissue microarray and immunohistochemical staining was used to detect the expression of FOXO1. The relationship between FOXO1 expression and clinicopathological parameters in patients with PCa was analyzed. Result: FOXO1 was highly expressed in BPH tissues, while FOXO1 expression in PCa tissues was significantly lower than that in BPH tissues(39.6% vs. 86.8%, P＜0.05). The expression of FOXO1 in low-middle-risk PCa tissues was significantly higher than that in high-risk PCa tissues(P＜0.05). FOXO1 expression was significantly correlated with PSA level, pathological T stage, lymph node metastasis and Gleason score in PCa(P＜0.05). The higher the Gleason score was, the lower the FOXO1 level was. However, the FOXO1 expression in PCa wasn't correlated with age, prostate volume or pathological positive margin(P＞0.05).Conclusion: FOXO1 is abnormally low expressed in PCa tissues, which is correlated with the invasion and metastasis of PCa. FOXO1 expression is closely related to PSA level, pathological T stage, lymph node metastasis and Gleason score in PCa.
- FOXO1 /
- prostate cancer /
- immunohistochemistry /
- pathological parameters

HTML全文

参考文献(16)

[1]	Siegel R L,Miller K D,Jemal A.Cancer Statistics,2017[J].CA Cancer J Clin,2017,67(1):7-30.
[2]	Chen W,Zheng R,Baade P D,et al.Cancer statistics in China,2015[J].CA Cancer J Clin,2016,66(2):115-132.
[3]	陈宝英,张英,黄胜超,等.FOXO1在乳腺癌中的表达及临床意义[J].海南医学,2017,28(9):1383-1386.
[4]	Zhao Y,Yang J,Liao W,et al.Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity[J].Nat Cell Biol,2010,12(7):665-675.
[5]	周英姿,张友元,桂律,等.FOXO1A及FLASH在胃癌组织中的表达及其意义[J].肿瘤防治研究,2010,37(6):675-678.
[6]	Huang H,Tindall D J.Dynamic FoxO transcription factors[J].J Cell Sci,2007,120(Pt 15):2479-2487.
[7]	Ma H Q,Liang X T,Zhao J J,et al.Decreased expression of Neurensin-2 correlates with poor prognosis in hepatocellular carcinoma[J].World J Gastroenterol,2009,15(38):4844-4848.
[8]	杨进益,杨明州,魏伟,等.前列腺癌发生发展的流行病学研究进展[J].临床泌尿外科杂志,2017,32(9):721-725.
[9]	Calabrò F,Sternberg C N.Current indications for chemotherapy in prostate cancer patients[J].Eur Urol,2007,51(1):17-26.
[10]	金益,邵钦树.FOXO1基因在肿瘤中的研究进展[J].肿瘤学杂志,2015,21(2):81-85.
[11]	Ha S,Ruoff R,Kahoud N,et al.Androgen receptor levels are upregulated by Akt in prostate cancer[J].Endocr Relat Cancer,2011,18(2):245-255.
[12]	Liu X,Choi R Y,Jawad S M,et al.Androgen-induced PSA expression requires not only activation of AR but also endogenous IGF-I or IGF-I/PI3K/Akt signaling in human prostate cancer epithelial cells[J].Prostate,2011,71(7):766-777.
[13]	Li R,Erdamar S,Dai H,et al.Forkhead protein FKHR and its phosphorylated form p-FKHR in human prostate cancer[J].Hum Pathol,2007,38(10):1501-1507.
[14]	Ma Q,Fu W,Li P,et al.FoxO1 mediates PTEN suppression of androgen receptor N-and C-terminal interactions and coactivator recruitment[J].Mol Endocrinol,2009,23(2):213-225.
[15]	Dong X Y,Chen C,Sun X,et al.FOXO1A is a candidate for the 13q14 tumor suppressor gene inhibiting androgen receptor signaling in prostate cancer[J].Cancer Res,2006,66(14):6998-7006.
[16]	Jiang J T,Huang H J.Targeting the Androgen Receptor by Taxol in Castration-Resistant Prostate Cancer[J].Mol Cell Pharmacol,2010,2(1):1-5.