长链非编码RNA UCA1在膀胱癌中的研究进展

钟远堂; 谢喜娜; 王翰; 吴诚龙; 唐爱发

doi:10.13201/j.issn.1001-1420.2019.08.018

长链非编码RNA UCA1在膀胱癌中的研究进展

- 1. 深圳大学第一附属医院/深圳市第二人民医院泌尿外科广东省泌尿生殖肿瘤系统与合成生物学重点实验室国家区域关键技术癌症基因组学临床应用工程实验室(广东深圳, 518035);
- 2. 广州医科大学研究生院
基金项目:
深圳市科技计划项目（编号JSGG20160301162913683）；深圳医疗卫生三名工程项目（编号SZSM201612031）；广东省科技创新战略专项资金项目（编号20178030301015）

详细信息

通讯作者: 唐爱发,E-mail:tangaifa2004@163.com

中图分类号: R737.14

收稿日期: 2018-05-09

Research progress of long noncoding RNA UCA1 in bladder cancer

- 1. Department of Urology, Shenzhen Second People's Hospital/First Affiliated Hospital of Shenzhen University, Guangdong Key Laboratory of Systems Biology and Synthetic Biology for Urogenital Tumors, National-Regional Key Technology Engineering Laboratory for Clinical Application of Cancer Genomics, Shenzhen, Guangdong, 518035, China;
- 2. Graduate School of Guangzhou Medical University

More Information

Corresponding author: TANG Aifa, E-mail: tangaifa2004@163.com

Received Date: 09 May 2018

摘要

摘要: 近年来，随着对长链非编码RNA （lncRNA）研究的不断深入，lncRNA在肿瘤发生发展中的作用受到越来越广泛的关注。其中，lncRNA尿路上皮癌相关抗原1（UCA1）在膀胱癌、胃癌、肝癌、卵巢癌等多种肿瘤组织中呈高表达，并参与了肿瘤的发生与发展。本文就UCA1与膀胱癌的关系作一综述。
- 长链非编码RNA /
- 尿路上皮癌相关抗原1 /
- 膀胱癌
Abstract: With the development of long noncoding RNA (lncRNA) research, more and more attention have been paid to the role of lncRNA in tumorigenesis and development.Among them, lncRNA urothelial carcinoma associated antigen 1 (lncRNA UCA1) is highly expressed in bladder cancer, gastric cancer, liver cancer, ovarian cancer and other tumor tissues, and is closely related to the occurrence and development of tumors.This article reviews the relationship between lncRNA UCA1 and bladder cancer.
- long noncoding RNA /
- urothelial carcinoma associated antigen 1 /
- bladder cancer

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参考文献(35)

[1]	Babjuk M, Burger M, Compérat E, et al.EAU Guidelines on Non-Muscle-invasive Urothelial Carcinoma of the Bladder:Update 2016[J].Eur Urol, 2017, 71 (3):447-461.
[2]	Siegel R L, Miller K D, Jemal A.Cancer statistics, 2018[J].CA Cancer J Clin, 2018, 68 (1):7-30.
[3]	Siegel R, Ma J, Zou Z, et al.Cancer statistics, 2014[J].CA Cancer J Clin, 2014, 64 (1):9-29.
[4]	Burger M, Oosterlinck W, Konety B, et al.ICUD-EAUInternational Consultation on Bladder Cancer 2012:Non-muscle-invasive urothelial carcinoma of the bladder[J].Eur Urol, 2013, 63 (1):36-44.
[5]	余淦, 陶启业, 欧正岳, 等.长链非编码RNA PTENP1在膀胱癌中的表达调控及功能研究[J].临床泌尿外科杂志, 2017, 32 (10):746-750.
[6]	Wang Z, Wang X, Zhang D, et al.Long non-coding RNA urothelial carcinoma-associated 1as a tumor biomarker for the diagnosis of urinary bladder cancer[J].Tumour Biol, 2017, 39 (6):1010428317709990.
[7]	Li F, Hu C P.Long Non-Coding RNA Urothelial Carcinoma Associated 1 (UCA1):Insight into Its Role in Human Diseases[J].Crit Rev Eukaryot Gene Expr, 2015, 25 (3):191-197.
[8]	Wang X S, Zhang Z, Wang H C, et al.Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma[J].Clin Cancer Res, 2006, 12 (16):4851-4858.
[9]	Wang F, Li X, Xie X, et al.UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion[J].FEBSLett, 2008, 582 (13):1919-1927.
[10]	Xue M, Chen W, Li X.Urothelial cancer associated 1:a long noncoding RNA with a crucial role in cancer[J].JCancer Res Clin Oncol, 2016, 142 (7):1407-1419.
[11]	Wang Y, Chen W, Yang C, et al.Long non-coding RNA UCA1a (CUDR) promotes proliferation and tumorigenesis of bladder cancer[J].Int J Oncol, 2012, 41 (1):276-284.
[12]	Wang B, Huang Z, Gao R, et al.Expression of Long Noncoding RNA Urothelial Cancer Associated 1 Promotes Cisplatin Resistance in Cervical Cancer[J].Cancer Biother Radiopharm, 2017, 32 (3):101-110.
[13]	Shang C, Guo Y, Zhang J, et al.Silence of long noncoding RNA UCA1 inhibits malignant proliferation and chemotherapy resistance to adriamycin in gastric cancer[J].Cancer Chemother Pharmacol, 2016, 77 (5):1061-1067.
[14]	Liu H, Wang G, Yang L, et al.Knockdown of Long Non-Coding RNA UCA1 Increases the Tamoxifen Sensitivity of Breast Cancer Cells through Inhibition of Wnt/beta-Catenin Pathway[J].PLoS One, 2016, 11 (12):e0168406.
[15]	Bian Z, Jin L, Zhang J, et al.LncRNA-UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p[J].Sci Rep, 2016, 6:23892.
[16]	Xue M, Li X, Wu W, et al.Upregulation of long noncoding RNA urothelial carcinoma associated 1 by CCAAT/enhancer binding protein alpha contributes to bladder cancer cell growth and reduced apoptosis[J].Oncol Rep, 2014, 31 (5):1993-2000.
[17]	Tu Z, Zhuang X, Yao Y G, et al.Is Required for Formation of Senescence-Associated Heterochromatin Foci Induced by Oncogenic RAS or BRCA1 Loss[J].Mol Cell Biol, 2013, 33 (9):1819-1829.
[18]	Kang H, Cui K, Zhao K.BRG1 controls the activity of the retinoblastoma protein via regulation of p21CIP1/WAF1/SDI[J].Mol Cell Biol, 2004, 24 (3):1188-1199.
[19]	Wang X, Gong Y, Jin B, et al.Long non-coding RNAurothelial carcinoma associated 1induces cell replication by inhibiting BRG1 in 5637cells[J].Oncol Rep, 2014, 32 (3):1281-1290.
[20]	Xie X, Pan J, Wei L, et al.Gene expression profiling of microRNAs associated with UCA1 in bladder cancer cells[J].Int J Oncol, 2016, 48 (4):1617-1627.
[21]	Wang T, Yuan J, Feng N, et al.Hsa-miR-1downregulates long non-coding RNA urothelial cancer associated1 in bladder cancer[J].Tumour Biol, 2014, 35 (10):10075-10084.
[22]	Leucci E, Patella F, Waage J, et al.microRNA-9targets the long non-coding RNA MALAT1 for degradation in the nucleus[J].Sci Rep, 2013, 3:2535-2535.
[23]	Wu W, Zhang S, Li X, et al.Ets-2regulates cell apoptosis via the Akt pathway, through the regulation of urothelial cancer associated 1, a long non-coding RNA, in bladder cancer cells[J].PLoS One, 2013, 8 (9):e73920.
[24]	Xue M, Li X, Li Z, et al.Urothelial carcinoma associated1 is a hypoxia-inducible factor-1alpha-targeted long noncoding RNA that enhances hypoxic bladder cancer cell proliferation, migration, and invasion[J].Tumour Biol, 2014, 35 (7):6901-6912.
[25]	Xue M, Pang H, Li X, et al.Long non-coding RNAurothelial cancer-associated 1promotes bladder cancer cell migration and invasion by way of the hsa-miR-145-ZEB1/2-FSCN1 pathway[J].Cancer Sci, 2016, 107 (1):18-27.
[26]	Luo J, Chen J, Li H, et al.LncRNA UCA1 promotes the invasion and EMT of bladder cancer cells by regulating the miR-143/HMGB1 pathway[J].Oncol Lett, 2017, 14 (5):5556-5562.
[27]	Xue M, Chen W, Xiang A, et al.Hypoxic exosomes facilitate bladder tumor growth and development through transferring long non-coding RNA-UCA1[J].Mol Cancer, 2017, 16 (1):143-143.
[28]	Yang C, Li X, Wang Y, et al.Long non-coding RNAUCA1 regulated cell cycle distribution via CREBthrough PI3-K dependent pathway in bladder carcinoma cells[J].Gene, 2012, 496 (1):8-16.
[29]	Shaw R J.Glucose metabolism and cancer[J].Curr Opin Cell Biol, 2006, 18 (6):598-608.
[30]	Cairns R A, Harris I S, Mak T W.Regulation of cancer cell metabolism[J].Nat Rev Cancer, 2011, 11 (2):85-95.
[31]	Li Z, Li X, Wu S, et al.Long non-coding RNA UCA1 promotes glycolysis by upregulating hexokinase 2through the mTOR-STAT3/microRNA143 pathway[J].Cancer Sci, 2014, 105 (8):951-955.
[32]	Aqeilan R I, Calin G A, Croce C M.miR-15aand miR-16-1in cancer:discovery, function and future perspectives[J].Cell Death Differ, 2010, 17 (2):215-220.
[33]	Li H J, Li X, Pang H, et al.Long non-coding RNAUCA1 promotes glutamine metabolism by targeting miR-16in human bladder cancer[J].Jpn J Clin Oncol, 2015, 45 (11):1055-1063.
[34]	Fan Y, Shen B, Tan M, et al.Long non-coding RNAUCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling[J].FEBS J, 2014, 281 (7):1750-1758.
[35]	Pan J, Li X, Wu W, et al.Long non-coding RNA UCA1 promotes cisplatin/gemcitabine resistance through CREB modulating miR-196a-5p in bladder cancer cells[J].Cancer Lett, 2016, 382 (1):64-76.