Effect of anisodamine hydrobromide on the perioperative period of flexible ureteroscopic lithotripsy by Ho:YAG laser
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摘要: 目的：探讨氢溴酸山莨菪碱应用于经尿道输尿管软镜钬激光碎石术对患者术后康复的影响。方法：选取2016年10月~2018年2月接受经尿道输尿管软镜钬激光碎石术的患者160例，其中82例围手术期采用氢溴酸山良菪碱加常规抗感染治疗（治疗组），78例采用常规抗感染支持治疗（对照组）。比较两组实验室检查指标、疼痛、血尿情况及并发症情况。结果：两组术后24 h的白细胞计数、中性粒细胞比值、术后24、72 h血肌酐变化值、疼痛评分、血尿持续时间及并发症发生情况比较差异有统计学意义（P<0.05）；两组患者术后72 h白细胞计数、中性粒细胞比值、术后24、72 h的血肌酐值、术后24、72 h的尿素氮及尿素氮变化值、手术并发症发生率比较差异无统计学意义。治疗组不良反应发生率明显低于对照组，差异有统计学意义（P<0.05）。结论：氢溴酸山莨菪碱应用于输尿管软镜钬激光碎石术围手术期可减少患者炎症反应，减轻疼痛，减少血尿时间，安全性佳，对加快经尿道输尿管软镜钬激光碎石术患者的术后康复有积极意义。Abstract: Objective: To study the effect of anisodamine hydrobromide on the perioperative period of flexible ureteroscopic lithotripsy by Ho:YAG laser. Method: A total of 160 patients who were treated by flexible ureteroscopy with holmium laser between October 2016 and February 2018 were enrolled. Among them, 82 patients were treated with anisodamine hydrobromide and conventional therapy during perioperative period, and the other 78 patients were treated with conventional therapy. Two groups of laboratory examination indicators, pain, duration of visible hematuria and postoperative complications were compared. Result: There was statistically significant difference in white blood cell count, neutrophil ratio, serum creatinine increase level between the two groups at 24 hours postoperatively. The patient's pain, duration of visible hematuria and postoperative complications also showed statistically significant difference. However, there was no statistically significant difference in white blood cell count, neutrophil percentage, incidence of postoperative complications at 72 hours postoperatively, urea nitrogen at 24 hours or 72 hours postoperatively, serum creatinine level at 24 hours or 72 hours postoperatively between two groups.Conclusion: Anisodamine hydrobromide can be used to reduce inflammatory reaction, relieve pain and reduce duration of hematuria in perioperative period for patients who were treated by flexible ureteroscopy with holmium laser, so It is helpful to accelerate patients' recovery.
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Key words:
- anisodamine hydrobromide /
- ureteral stone /
- flexible ureteroscope /
- accelerate recovery
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[1] 王翔, 黎承杨, 汪小明, 等.电子输尿管软镜与纤维输尿管软镜治疗上尿路结石的疗效对比研究[J].临床泌尿外科杂志, 2018, 33(2):93-95, 100.
[2] 侯飞飞.输尿管软镜碎石术中肾盂内压力的监控及意义[J].中国微创外科杂志, 2018, 18(1):75-77.
[3] Geraghty R, Abourmarzouk O, Rai B, et al.Evidence for Ureterorenoscopy and Laser Fragmentation(URSL) for Large Renal Stones in the Modern Era[J].Curr Urol Rep, 2015, 16(8):54.
[4] Hyams E S, Munver R, Bird V G, et al.Flexible ureterorenoscopy and holmium laser lithotripsy for the management of renal stone burdens that measure 2 to 3 cm:a multi-institutional experience[J].J Endourol, 2010, 24(10):1583-1588.
[5] Resorlu B, Unsal A.Comparison of percutaneous nephrolithotomy and retrograde flexible nephrolithotripsy for the management of 2-4 cm stones:a matched-pair analysis[J].BJU Int, 2012, 109(9):E4-E5.
[6] 潘铁军, 刘伟, 杨家荣, 等.输尿管软镜块状碎石法结合取石篮在治疗肾结石中的运用[J].临床泌尿外科杂志, 2018, 33(2):126-128.
[7] 岳茂兴.山莨菪碱联用地塞米松治疗术后并发多器官功能障碍综合征的临床研究方案[J].中国中西医结合急救杂志, 2004, 11(5):264-267.
[8] 张维颉, 李科威, 顾润国.输尿管镜碎石术中上尿路尿动力学变化对术后肾功能的影响[J].山东医学高等专科学校学报, 2015, 37(4):241-244.
[9] 操作亮, 刘双林, 袁敬东, 等.持续肾盂内压监测在微创经皮肾镜碎石术中的应用及其临床意义[J].临床外科杂志, 2012, 20(8):583-584.
[10] 尹广, 陈欣.急性肾损伤的定义及其临床诊断新标准[J].西部医学, 2013, 25(12):1916-1918.
[11] 蔡广研, 卜茹.急性肾损伤概念和诊断标准的变迁[J].中华肾病研究电子杂志, 2013, 2(3):115-119.
[12] Joannidis M, Metnitz B, Bauer P, et al.Acute kidney injury in critically ill patients classified by AKIN versus RIFLE using the SAPS 3 database[J].Intensive Care Med, 2009, 35(10):1692-1702.
[13] 万学红, 卢雪峰.诊断学[M].8版.北京:人民卫生出版社, 2013:344-345.
[14] 苏华田, 王海春.对山莨菪碱救治感染性休克的重新认识和展望[J].中华危重病急救医学, 2015, 27(1):10-12.
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